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doi: 10.1146/annurev-bioeng-062117-121224 95 YanJHorngT

In contrast, iron overload induced significant downregulation of ACSL4 and GPX4 expression in these cells, suggesting a disruption in lipid homeostasis and a reduction in antioxidant defense mechanisms, which may contribute to the progression of iron-induced ferroptosis

10.1007/s12035-025-04703-0 61 LiY.JiangJ.LiJ.LiuS.WangC.YuZ.et al (2025b)

For studies with a calorie-restricted and body-weight-loss-matched control group, HFHS diet (58 kcal% fat, D12331i, Research Diets) was weighed and provided as one separate pellet per mouse at the time of injection